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T Follicular Helper Cells During Immunity and Tolerance

Linterman, Michelle; Garcia De Vinuesa, Maria Carola

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Helper T cells are required for the generation of a potent immune response to foreign antigens. Amongst them, T follicular helper (Tfh) cells are specialized in promoting protective, long-lived antibody responses that arise from germinal centers. Within these structures, the specificity of B cell receptors may change, due to the process of random somatic hypermutation aimed at increasing the overall affinity of the antibody response. The danger of emerging self-reactive specificities is offset...[Show more]

dc.contributor.authorLinterman, Michelle
dc.contributor.authorGarcia De Vinuesa, Maria Carola
dc.date.accessioned2015-12-08T22:42:05Z
dc.identifier.isbn9780123812841
dc.identifier.urihttp://hdl.handle.net/1885/36934
dc.description.abstractHelper T cells are required for the generation of a potent immune response to foreign antigens. Amongst them, T follicular helper (Tfh) cells are specialized in promoting protective, long-lived antibody responses that arise from germinal centers. Within these structures, the specificity of B cell receptors may change, due to the process of random somatic hypermutation aimed at increasing the overall affinity of the antibody response. The danger of emerging self-reactive specificities is offset by a stringent selection mechanism delegated in great part to Tfh cells. Only those B cells receiving survival signals from Tfh cells can exit the germinal centers to join the long-lived pools of memory B cells and bone marrow-homing plasma cells. Thus, a crucial immune tolerance checkpoint to prevent long-term autoantibody production lies in the ability to tolerize Tfh cells and to control positive and negative selection signals delivered by this subset. This review tackles the known mechanisms that ensure Tfh tolerance, many of them shared by other T helper subsets during thymic development and priming, but others unique to Tfh cells. Amongst the latter are checkpoints at the stages of Tfh differentiation, follicular migration, growth, longevity, and quality control of selection signals. Finally, we also discuss the consequences of a breakdown in Tfh tolerance.
dc.publisherElsevier
dc.relation.ispartofProgress in Molecular Biology and Translational Science
dc.subjectKeywords: animal; autoimmunity; cell differentiation; cytology; helper cell; human; immunological tolerance; immunology; regulatory T lymphocyte; review; Animals; Autoimmunity; Cell Differentiation; Humans; Immune Tolerance; T-Lymphocytes, Helper-Inducer; T-Lymphoc Autoimmunity; Germinal center; T follicular helper cells; Tolerance
dc.titleT Follicular Helper Cells During Immunity and Tolerance
dc.typeBook chapter
local.description.notesImported from ARIES
dc.date.issued2010
local.identifier.absfor110704 - Cellular Immunology
local.identifier.ariespublicationu6800332xPUB142
local.type.statusPublished Version
local.contributor.affiliationLinterman, Michelle A., Cambridge Institute for Medical Research
local.contributor.affiliationGarcia De Vinuesa, Maria Carola, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.startpage207
local.bibliographicCitation.lastpage248
local.identifier.doi10.1016/S1877-1173(10)92009-7
dc.date.updated2016-02-24T11:37:54Z
local.bibliographicCitation.placeofpublicationUSA
local.identifier.scopusID2-s2.0-77958138084
CollectionsANU Research Publications

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