T Follicular Helper Cells During Immunity and Tolerance
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Linterman, Michelle; Garcia De Vinuesa, Maria Carola
Description
Helper T cells are required for the generation of a potent immune response to foreign antigens. Amongst them, T follicular helper (Tfh) cells are specialized in promoting protective, long-lived antibody responses that arise from germinal centers. Within these structures, the specificity of B cell receptors may change, due to the process of random somatic hypermutation aimed at increasing the overall affinity of the antibody response. The danger of emerging self-reactive specificities is offset...[Show more]
Collections | ANU Research Publications |
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Date published: | 2010 |
Type: | Book chapter |
URI: | http://hdl.handle.net/1885/36934 |
Book Title: | Progress in Molecular Biology and Translational Science |
DOI: | 10.1016/S1877-1173(10)92009-7 |
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01_Linterman_T_Follicular_Helper_Cells_2010.pdf | 1.05 MB | Adobe PDF | Request a copy |
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