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T-type Ca2+ Channels Facilitate NO-formation, Vasodilatation and NO-mediated Modulation of Blood Pressure

Svenningsen, Per; Andersen, Kenneth; Thuesen, Anne D; Shin, Hee-Sup; Vanhoutte, Paul M.; Skott, Ole; Jensen, Boye L; Hill, Caryl; Hansen, Pernille


Voltage-gated calcium channels are involved in the vascular excitation-contraction mechanism and regulation of arterial blood pressure. It was hypothesized that T-type channels promote formation of nitric oxide from the endothelium. The present experiments determine the involvement of T-type channels in depolarization-dependent dilatation of mesenteric arteries and blood pressure regulation in Cav3.1 knock-out mice. Nitric oxide-dependent vasodilatation following depolarization-mediated...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Pflugers Archives European Journal of Physiology
DOI: 10.1007/s00424-014-1492-4


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