T-type Ca2+ Channels Facilitate NO-formation, Vasodilatation and NO-mediated Modulation of Blood Pressure
Voltage-gated calcium channels are involved in the vascular excitation-contraction mechanism and regulation of arterial blood pressure. It was hypothesized that T-type channels promote formation of nitric oxide from the endothelium. The present experiments determine the involvement of T-type channels in depolarization-dependent dilatation of mesenteric arteries and blood pressure regulation in Cav3.1 knock-out mice. Nitric oxide-dependent vasodilatation following depolarization-mediated...[Show more]
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|Source:||Pflugers Archives European Journal of Physiology|
|01_Svenningsen_T-type_Ca2+_Channels_2014.pdf||633.48 kB||Adobe PDF||Request a copy|
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