Skip navigation
Skip navigation

T-type Ca2+ Channels Facilitate NO-formation, Vasodilatation and NO-mediated Modulation of Blood Pressure

Svenningsen, Per; Andersen, Kenneth; Thuesen, Anne D; Shin, Hee-Sup; Vanhoutte, Paul M.; Skott, Ole; Jensen, Boye L; Hill, Caryl; Hansen, Pernille

Description

Voltage-gated calcium channels are involved in the vascular excitation-contraction mechanism and regulation of arterial blood pressure. It was hypothesized that T-type channels promote formation of nitric oxide from the endothelium. The present experiments determine the involvement of T-type channels in depolarization-dependent dilatation of mesenteric arteries and blood pressure regulation in Cav3.1 knock-out mice. Nitric oxide-dependent vasodilatation following depolarization-mediated...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
URI: http://hdl.handle.net/1885/36924
Source: Pflugers Archives European Journal of Physiology
DOI: 10.1007/s00424-014-1492-4

Download

File Description SizeFormat Image
01_Svenningsen_T-type_Ca2+_Channels_2014.pdf633.48 kBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator