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Identification of active site residues in the Shigella flexneri glucosyltransferase GtrV

Moscoso, Joana; Korres, Haralambos; George, Divya; Verma, Naresh


The serotype-specific glucosyltransferase, GtrV, is responsible for glucosylation of the O-antigen repeating unit of Shigella flexneri serotype 5a strains. GtrV is an integral inner membrane protein with two essential periplasmic loops: the large Loop 2 and the C-terminal Loop 10. In this study, the full length of the Loop 2 was shown to be necessary for GtrV function. Site-directed mutagenesis within this loop revealed that conserved aromatic and charged amino acids have a critical role in the...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Molecular Membrane Biology
DOI: 10.3109/09687680903581267


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