Bulk Segregation Mapping of Mutations in Closely Related Strains of Mice
Xia, Yu; Won, Sungyong; Du, Xin; Pei, Lin; Ross, Charles; La Vine, Diantha; Wiltshire, Sean; Vidal, Sillvia M.; Whittle, Belinda; Goodnow, Christopher; Koziol, James; Moresco, Eva Marie Y.; Beutler, Bruce
Phenovariance may be obscured when genetic mapping is performed using highly divergent strains, and closely similar strains are preferred if adequate marker density can be established. We sequenced the C57BL/10J mouse genome using the Applied Biosystems SOLiD platform and here describe a genomewide panel of informative markers that permits the mapping of mutations induced on the closely related C57BL/6J background by outcrossing to C57BL/10J, and backcrossing or intercrossing. The panel...[Show more]
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