Incidence of Breast Cancer and Its Subtypes in Relation to Individual and Multiple Low-Penetrance Genetic Susceptibility Loci
Reeves, Gillian K; Travis, Ruth; Green, Jane; Bull, Diana; Tipper, Sarah J; Baker, Krys; Beral, Valerie; Peto, Richard; Bell, John I; Zelenkia, Diana; Lathrop, Mark; Banks, Emily; English, Ruth; Patnick, Julietta; Vessey, Martin; Wallis, Matthew; Million Women Study, Collaborators
Context: There is limited evidence on how the risk of breast cancer and its subtypes depend on low-penetrance susceptibility loci, individually or in combination. Objective: To analyze breast cancer risk, overall and by tumor subtype, in relation to 14 individual single-nucleotide polymorphisms (SNPs) previously linked to the disease, and in relation to a polygenic risk score. Design, Setting, and Participants: Study of 10 306 women with breast cancer (mean age at diagnosis, 58 years) and 10...[Show more]
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|Source:||JAMA: The Journal of the American Medical Association|
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