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Human Equilibrative Nucleoside Transporter 1 Levels Predict Response to Gemcitabine in Patients With Pancreatic Cancer

Farrell, James; Elsaleh, Hany; Garcia, Miguel; Lai, Raymond; Ammar, Ali; Regine, William; Abrams, Ross; Benson, Bowen; Macdonald, John; Cass, Carol; Dicker, Adam; Mackey, John


Background & Aims: The human equilibrative nucleoside transporter (hENT1) protein transports gemcitabine into cells. Small retrospective studies in pancreatic cancer suggest that levels of hENT1 protein or messenger RNA may have prognostic value. We studied the predictive value of hENT1 levels in a cohort of pancreatic adenocarcinoma patients from the large prospective randomized adjuvant treatment trial RTOG9704. Methods: In RTOG9704, 538 patients were assigned randomly, after surgical...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Gastroenterology
DOI: 10.1053/j.gastro.2008.09.067


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