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White Matter Hyperintensities in the Forties: Their prevalence and topography in an epidemiological sample aged 44-48

Wen, Wei; Sachdev, Perminder Singh; Li, Jason; Chen, Xiaohua; Anstey, Kaarin


White matter hyperintensities (WMHs) are a frequent finding on T2-weighted MRI of the brain in elderly individuals, but their prevalence and severity in younger asymptomatic populations is less well studied. We report the topography of WMHs on T2-weighted fluid inversion recovery (FLAIR) MRI in 428 individuals aged 44-48 years recruited randomly from a healthy community sample. WMHs were delineated from FLAIR and T1-weighted scans by using a computer algorithm, further verified and then...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Human Brain Mapping
DOI: 10.1002/hbm.20586


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