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Multiple checkpoints keep follicular helper T cells under control to prevent autoimmunity

Yu, Di; Garcia De Vinuesa, Maria Carola

Description

Follicular helper T (Tfh) cells select mutated B cells in germinal centres, which can then differentiate into long-lived high affinity memory B cells and plasma cells. Tfh cells are regulated by a unique molecular programme orchestrated by the transcriptional repressor Bcl6. This transcription factor turns down expression of multiple genes, including transcriptional regulators of other T helper lineages and a vast amount of microRNAs. This enables Tfh cells to express a suite of chemokine...[Show more]

dc.contributor.authorYu, Di
dc.contributor.authorGarcia De Vinuesa, Maria Carola
dc.date.accessioned2015-12-08T22:41:44Z
dc.identifier.issn1672-7681
dc.identifier.urihttp://hdl.handle.net/1885/36777
dc.description.abstractFollicular helper T (Tfh) cells select mutated B cells in germinal centres, which can then differentiate into long-lived high affinity memory B cells and plasma cells. Tfh cells are regulated by a unique molecular programme orchestrated by the transcriptional repressor Bcl6. This transcription factor turns down expression of multiple genes, including transcriptional regulators of other T helper lineages and a vast amount of microRNAs. This enables Tfh cells to express a suite of chemokine receptors, stimulatory ligands and cytokines that enable migration into B-cell follicles, and provision of effective help to B cells. Not surprisingly, dysregulation of this powerful helper subset can lead to a range of autoantibody-mediated diseases; indeed, aberrant accumulation of Tfh cells has been linked with systemic lupus erythematosus, Sjogren's disease and autoimmune arthritis. Here we dissect multiple checkpoints that operate throughout Tfh cell development and maturation to maintain immunological tolerance while mounting robust and long-lasting antibody responses.
dc.publisherChinese Society of Immunology
dc.sourceCellular and Molecular Immunology
dc.subjectKeywords: CD40 ligand; chemokine receptor CXCR5; interleukin 21; interleukin 21 receptor; protein bcl 2; protein bcl 6; protein bcl xl; signaling lymphocyte activation molecule associated protein; T lymphocyte receptor; antibody response; autoimmunity; B lymphocyte autoimmunity; germinal centre; Tfh
dc.titleMultiple checkpoints keep follicular helper T cells under control to prevent autoimmunity
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume7
dc.date.issued2010
local.identifier.absfor110704 - Cellular Immunology
local.identifier.ariespublicationu6800332xPUB140
local.type.statusPublished Version
local.contributor.affiliationYu, Di, Garvan Institute of Medical Research
local.contributor.affiliationGarcia De Vinuesa, Maria Carola, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.startpage198
local.bibliographicCitation.lastpage203
local.identifier.doi10.1038/cmi.2010.18
local.identifier.absseo920108 - Immune System and Allergy
dc.date.updated2016-02-24T11:37:53Z
local.identifier.scopusID2-s2.0-77953240156
local.identifier.thomsonID000277282200006
CollectionsANU Research Publications

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