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Multiple checkpoints keep follicular helper T cells under control to prevent autoimmunity

Yu, Di; Garcia De Vinuesa, Maria Carola


Follicular helper T (Tfh) cells select mutated B cells in germinal centres, which can then differentiate into long-lived high affinity memory B cells and plasma cells. Tfh cells are regulated by a unique molecular programme orchestrated by the transcriptional repressor Bcl6. This transcription factor turns down expression of multiple genes, including transcriptional regulators of other T helper lineages and a vast amount of microRNAs. This enables Tfh cells to express a suite of chemokine...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Cellular and Molecular Immunology
DOI: 10.1038/cmi.2010.18


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