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The transcription repressor, ZEB1, cooperates with CtBP2 and HDAC1 to suppress IL-2 gene activation in T cells

Wang, Jun; Lee, Seung Soo; Teh, Charis; Bunting, Karen; Ma, Lina; Shannon, M Frances


Activation of T cells leads to the induction of many cytokine genes that are required for appropriate immune responses, including IL-2, a key cytokine for T cell proliferation and homeostasis. The activating transcription factors such as nuclear factor of activated T cells, nuclear factor κB/Rel and activated protein-1 family members that regulate inducible IL-2 gene expression have been well documented. However, negative regulation of the IL-2 gene is less studied. Here we examine the role of...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: International Immunology
DOI: 10.1093/intimm/dxn143


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