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Functional characteristics of the malaria parasite's 'chloroquine resistance transporter' implications for chemotherapy

Summers, Robert; Martin, Rowena


Chloroquine (CQ) was the best and most heavily used drug in the fight against malaria. However, the effectiveness of CQ has declined with the emergence and spread of CQ-resistant (CQR) Plasmodium falciparum parasites. The primary determinant of CQ resistance in P. falciparum is mutations in the parasite's 'chloroquine resistance transporter' (PfCRT). These mutations result in a marked reduction in the accumulation of CQ by the parasite; however the mechanism by which this is achieved was not...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Virulence


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