Two siblings with lethal pneumococcal meningitis in a family with a mutation in Interleukin-1 receptor associated kinase 4
We describe two siblings with one confirmed and one inferred homozygous base pair deletion in the gene for interleukin-1-related kinase 4 (IRAK-4) who died of pneumococcal meningitis at 2 and 14 months, respectively. Interleukin-1-related kinase 4 deficiency is a potentially lethal immunodeficiency characterized by a poor inflammatory response to pyogenic infections.
|Collections||ANU Research Publications|
|Source:||Journal of Pediatrics|
|01_Enders_Two_siblings_with_lethal_2004.pdf||85.97 kB||Adobe PDF|
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