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The Alternative Complement Pathways Seems to be a UVA Sensor that Leads to Systemic Immunosuppression

Stapelberg, Michael P.F.; Williams, Rohan; Byrne, Scott N.; Halliday, Gary M.


UV wavebands in sunlight are immunomodulatory. About half the amount of UVA within a minimum erythemal dose of sunlight is systemically immunosuppressive, whereas higher doses protect from UVB immunosuppression in mice. We have earlier shown that these responses to UVA are genetically restricted, as they occur in C57BL/6 but not in Balb/c mice. We used gene set enrichment analysis of microarray data and real-time reverse transcriptase (RT)-PCR confirmation to determine the molecular mechanisms...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: The Journal of Investigative Dermatology
DOI: 10.1038/jid.2009.128


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