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Intra- and inter-individual genetic differences in gene expression

Cowley, Mark J.; Cotsapas, Chris J.; Williams, Rohan; Chan, Eva K F; Pulvers, Jeremy N.; Liu, Michael Y.; Luo, Oscar J.; Nott, D. J.; Little, Peter F. R.

Description

Genetic variation is known to influence the amount of mRNA produced by a gene. Because molecular machines control mRNA levels of multiple genes, we expect genetic variation in components of these machines would influence multiple genes in a similar fashion. We show that this assumption is correct by using correlation of mRNA levels measured from multiple tissues in mouse strain panels to detect shared genetic influences. These correlating groups of genes (CGGs) have collective properties that...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/36571
Source: Mammalian Genome
DOI: 10.1007/s00335-009-9181-x

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