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Heparan Sulfate-Dependent Signaling of Fibroblast Growth factor 18 by Chondrocyte-Derived Perlecan

Chuang, Christine Y; Lord, Megan S; Melrose, James; Rees, Martin D; Knox, Sarah M; Freeman, Craig; Iozzo, Renato V; Whitelock, John M


Perlecan is a large multidomain proteoglycan that is essential for normal cartilage development. In this study, perlecan was localized in the pericellular matrix of hypertrophic chondrocytes in developing human cartilage rudiments. Perlecan immunopurified from medium conditioned by cultured human fetal chondrocytes was found to be substituted with heparan sulfate (HS), chondroitin sulfate (CS), and keratan sulfate (KS). Ligand and carbohydrate engagement (LACE) assays demonstrated that...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Biochemistry
DOI: 10.1021/bi1005199


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