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Human Health Consequences of Use of Antimicrobial Agents in Aquaculture

Heuer, Ole; Kruse, Hilde; Grave, Kari; Collignon, Peter; Karunasagar, Iddya; Angulo, Frederick J

Description

Intensive use of antimicrobial agents in aquaculture provides a selective pressure creating reservoirs of drug-resistant bacteria and transferable resistance genes in fish pathogens and other bacteria in the aquatic environment. From these reservoirs, resistance genes may disseminate by horizontal gene transfer and reach human pathogens, or drug-resistant pathogens from the aquatic environment may reach humans directly. Horizontal gene transfer may occur in the aquaculture environment, in the...[Show more]

dc.contributor.authorHeuer, Ole
dc.contributor.authorKruse, Hilde
dc.contributor.authorGrave, Kari
dc.contributor.authorCollignon, Peter
dc.contributor.authorKarunasagar, Iddya
dc.contributor.authorAngulo, Frederick J
dc.date.accessioned2015-12-08T22:40:28Z
dc.identifier.issn1058-4838
dc.identifier.urihttp://hdl.handle.net/1885/36505
dc.description.abstractIntensive use of antimicrobial agents in aquaculture provides a selective pressure creating reservoirs of drug-resistant bacteria and transferable resistance genes in fish pathogens and other bacteria in the aquatic environment. From these reservoirs, resistance genes may disseminate by horizontal gene transfer and reach human pathogens, or drug-resistant pathogens from the aquatic environment may reach humans directly. Horizontal gene transfer may occur in the aquaculture environment, in the food chain, or in the human intestinal tract. Among the antimicrobial agents commonly used in aquaculture, several are classified by the World Health Organisation as critically important for use in humans. Occurrence of resistance to these antimicrobial agents in human pathogens severely limits the therapeutic options in human infections. Considering the rapid growth and importance of aquaculture industry in many regions of the world and the widespread, intensive, and often unregulated use of antimicrobial agents in this area of animal production, efforts are needed to prevent development and spread of antimicrobial resistance in aquaculture to reduce the risk to human health.
dc.publisherUniversity of Chicago Press
dc.sourceClinical Infectious Diseases
dc.subjectKeywords: amoxicillin; ampicillin; antibiotic agent; chloramphenicol; chlortetracycline; enrofloxacin; erythromycin; florfenicol; flumequine; furazolidone; neomycin; nitrofurantoin; oxolinic acid; oxytetracycline; streptomycin; sulfonamide; tetracycline; antibiotic
dc.titleHuman Health Consequences of Use of Antimicrobial Agents in Aquaculture
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume49
dc.date.issued2009
local.identifier.absfor110309 - Infectious Diseases
local.identifier.ariespublicationu4201517xPUB137
local.type.statusPublished Version
local.contributor.affiliationHeuer, Ole, Technical University of Denmark
local.contributor.affiliationKruse, Hilde, Norwegian School of Veterinary Science
local.contributor.affiliationGrave, Kari, Norwegian School of Veterinary Science
local.contributor.affiliationCollignon, Peter, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationKarunasagar, Iddya, Karnataka Veterinary, Animal & Fisheries Sciences University
local.contributor.affiliationAngulo, Frederick J, Centers for Disease Control and Prevention
local.description.embargo2037-12-31
local.bibliographicCitation.issue8
local.bibliographicCitation.startpage1248
local.bibliographicCitation.lastpage1253
local.identifier.doi10.1086/605667
dc.date.updated2016-02-24T10:40:41Z
local.identifier.scopusID2-s2.0-70349925330
CollectionsANU Research Publications

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