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Inter-individual variation in expression: a missing link in biomarker biology?

Little, Peter F R; Williams, Rohan; Wilkins, Marc R.

Description

The past decade has seen an explosion of variation data demonstrating that diversity of both protein-coding sequences and of regulatory elements of protein-coding genes is common and of functional importance. In this article, we argue that genetic diversity can no longer be ignored in studies of human biology, even research projects without explicit genetic experimental design, and that this knowledge can, and must, inform research. By way of illustration, we focus on the potential role of...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/36491
Source: Trends in Biotechnology
DOI: 10.1016/j.tibtech.2008.10.002

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