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Microvascular pathology in the aging human brain: Evidence that senile plaques are sites of microhaemorrhages

Cullen, Karen; Kocsi, Zoltan; Stone, Jonathan


Amyloid-rich plaques are a feature of the aging human cerebral cortex. We have recently described another feature of aging human cortex, microhaemorrhages, identified by their content of haem, red blood cells, collagen and clotting factors, and their spatial relationship to capillaries. Here we relate microhaemorrhages to amyloid deposits. Observations were made in three groups: patients with no history of dementia, patients with Alzheimer's disease (AD) and patients with Down's syndrome (DS)...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Neurobiology of Aging
DOI: 10.1016/j.neurobiolaging.2005.10.016


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