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STAT3 is required for IL-21-induced secretion of IgE from human naive B cells

Avery, Danielle T; Ma, Cindy; Bryant, Vanessa L; Santner-Nanan, Brigitte; Nanan, Ralph; Wong, Melanie; Fulcher, David; Cook, Matthew; Tangye, Stuart G

Description

The production of immunoglobulin E (IgE) is tightly regulated. This is evidenced by the fact that it comprises less than 0.0001% of serum Ig, and aberrant production causes atopic conditions, including allergy, rhinitis, and anaphylaxis. Interleukin-4 (IL-4) is a well-characterized inducer of IgE by human and murine B cells, whereas interferon-7 can antagonize this effect. IL-21 has also been recognized for its ability to suppress IL-4-induced IgE production by murine B cells. Here, we...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
URI: http://hdl.handle.net/1885/36422
Source: Blood
DOI: 10.1182/blood-2008-02-142745

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