Skip navigation
Skip navigation

Brownian dynamics investigation into the conductance state of the MscS channel crystal structure

Vora, Taira; Corry, Ben; Chung, Shin-Ho

Description

We suggest that the crystal structure of the mechanosensitive channel of small conductance is in a minimally conductive state rather than being fully activated. Performing Brownian dynamics simulations on the crystal structure show that no ions pass through it. When simulations are conducted on just the transmembrane domain (excluding the cytoplasmic residues 128 to 280) ions are seen to pass through the channel, but the conductance of ∼ 30 pS is well below experimentally measured values. The...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
URI: http://hdl.handle.net/1885/36378
Source: Biochimica et Biophysica Acta: International journal of Biochemistry and Biophysics
DOI: 10.1016/j.bbamem.2006.04.014

Download

File Description SizeFormat Image
01_Vora_Brownian_dynamics_2006.pdf302.21 kBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator