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Brownian dynamics investigation into the conductance state of the MscS channel crystal structure

Vora, Taira; Corry, Ben; Chung, Shin-Ho


We suggest that the crystal structure of the mechanosensitive channel of small conductance is in a minimally conductive state rather than being fully activated. Performing Brownian dynamics simulations on the crystal structure show that no ions pass through it. When simulations are conducted on just the transmembrane domain (excluding the cytoplasmic residues 128 to 280) ions are seen to pass through the channel, but the conductance of ∼ 30 pS is well below experimentally measured values. The...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Biochimica et Biophysica Acta: International journal of Biochemistry and Biophysics
DOI: 10.1016/j.bbamem.2006.04.014


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