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Changes in oxygen tension affect cardiac mitochondrial respiration rate via changes in the rate of mitochondrial hydrogen peroxide production

Di Maria, Carla; Bogoyevitch, Marie A; McKitrick, D.J; Arnolda, Leonard; Hool, Livia C; Arthur, Peter

Description

The capacity of mitochondria to respond to changes in oxygen delivery has the potential to affect the ability of the heart to tolerate decreased oxygen delivery. Respiration by mitochondria is typically regarded as independent of oxygen tension (pO2) until critically low oxygen concentrations limit the activity of cytochrome oxidase. Paradoxically, there is evidence that cellular and mitochondrial oxygen consumption (respiration) can decline at oxygen tensions well above this critical pO2. We...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/36338
Source: Journal of Molecular and Cellular Cardiology
DOI: 10.1016/j.yjmcc.2009.03.010

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