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Gene and noncoding RNA regulation underlying photoreceptor protection: microarray study of dietary antioxidant saffron and photobiomodulation in rat retina

Natoli, Riccardo; Zhu, Yuan; Valter (Valter-Kocsi), Krisztina; Bisti, Silvia; Eells, Janice; Stone, Jonathan


Purpose: To identify the genes and noncoding RNAs (ncRNAs) involved in the neuroprotective actions of a dietary antioxidant (saffron) and of photobiomodulation (PBM). Methods: We used a previously published assay of photoreceptor damage, in which albino Sprague Dawley rats raised in dim cyclic illumination (12 h 5 lux, 12 h darkness) were challenged by 24 h exposure to bright (1,000 lux) light. Experimental groups were protected against light damage by pretreatment with dietary saffron (1...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Molecular Vision


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