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Heparanase in Primary Human Osteoblasts

Smith, Paul; Freeman, Craig; Yu, Di; Chen, Ming-Ming; Gatenby, Paul; Li, Rachel; Parish, Christopher


Heparanase (HPSE) is known to be involved in fracture repair in mice, but its presence and function in human bone formation remains unclear. Our aim was to determine the expression of HPSE in human bone forming osteoblasts and to better understand its role in osteogenesis. HPSE protein expression and enzymatic activity were demonstrated in osteoblasts isolated from trabecular bone specimens of patients with osteoporosis (OP) and from healthy subjects, although the levels differed markedly....[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Journal of Orthopaedic Research
DOI: 10.1002/jor.21138


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