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Contribution of stromal cells to the migration, function and retention of plasma cells in human spleen: potential roles of CXCL12, IL-6 and CD54

Ellyard, Julia; Avery, Danielle T; Mackay, Charles R; Tangye, Stuart G


Plasma cells (PC) localize to discrete areas of secondary lymphoid tissue and bone marrow (BM). The positioning of PC in different sites is believed to be regulated by chemokines and adhesion molecules expressed by accessory cells in the lymphoid tissue microenvironment. However, the mechanisms responsible for the positioning of PC within the red pulp (RP) of human spleen have not been elucidated. Therefore, we examined the contribution of human splenic stromal cells to the migration and...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: European Journal of Immunology
DOI: 10.1002/eji.200425442


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