Chemokine and cytokine cooperativity: eosinophil migration in the asthmatic response
Eosinophils play a central role in the pathophysiology of allergic disease. The mechanisms that regulate eosinophil migration are complex; however, chemokines and cytokines produced in both the early and late phases of the asthmatic response appear to cooperate in eosinophil recruitment. In particular, there exists a unique synergy between eotaxin and IL-5. The role of chemokine/cytokine cooperativity has been investigated in the extra-cellular matrix, adhesion molecule/integrin interactions,...[Show more]
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|Source:||Immunology and Cell Biology|
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