Microarray Analysis of Hyperoxia Stressed Mouse Retina: Differential Gene Expression in the Inferior and Superior Region
Aim: Hyperoxia-induced photoreceptor degeneration occurs preferentially in the inferior retina of C57BL/6J mice. This study investigates differential gene expression in the inferior and superior retina of C57BL/6J mouse, before and after hyperoxic stress. Methods: At the age of P (postnatal day) 83-90, mice were placed in constant normoxia or hyperoxia (75% O2) for 2 weeks. Retinas from control and exposed mice were removed and RNA was extracted from superior and inferior regions. The RNA from...[Show more]
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