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Microarray Analysis of Hyperoxia Stressed Mouse Retina: Differential Gene Expression in the Inferior and Superior Region

Zhu, Yuan; Natoli, Riccardo; Valter (Valter-Kocsi), Krisztina; Stone, Jonathan


Aim: Hyperoxia-induced photoreceptor degeneration occurs preferentially in the inferior retina of C57BL/6J mice. This study investigates differential gene expression in the inferior and superior retina of C57BL/6J mouse, before and after hyperoxic stress. Methods: At the age of P (postnatal day) 83-90, mice were placed in constant normoxia or hyperoxia (75% O2) for 2 weeks. Retinas from control and exposed mice were removed and RNA was extracted from superior and inferior regions. The RNA from...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Book chapter
Book Title: Retinal Degenerative Diseases: Laboratory and Therapeutic Investigations
DOI: 10.1007/978-1-4419-1399-9_25


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