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Antiviral protection following immunization correlates with humoral but not cell-mediated immunity

Panchanathan, Vijay; Chaudhri, Geeta; Karupiah, Gunasegaran

Description

Smallpox was a deadly disease when it was rife yet despite its eradication more than 30 years ago, the possibility of accidental or intentional release has driven research in search of better definitions of correlates of protective immunity. Mousepox, a disease caused by ectromelia virus (ECTV), is arguably one of the best surrogate small animal models for smallpox. Correlates of protection in mousepox are well defined during primary infection, whereas those in a secondary infection, which have...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
URI: http://hdl.handle.net/1885/36125
Source: Immunology and Cell Biology
DOI: 10.1038/icb.2009.110

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