The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs
Athanasopoulos, Vicki; Barker, Andrew; Yu, Di; Tan, Andy; Srivastava, Monika; Contreras, Nelida; Wang, Jianbin; Lam, Kong Peng; Brown, Simon H.J.; Goodnow, Christopher; Dixon, Nicholas Edward; Leedman, Peter J; Saint, Robert; Garcia De Vinuesa, Maria Carola
Roquin is an E3 ubiquitin ligase with a poorly understood but essential role in preventing T-cell-mediated autoimmune disease and in microRNA-mediated repression of inducible costimulator (Icos) mRNA. Roquin and its mammalian paralogue membrane-associated nucleic acid binding protein (MNAB) define a protein family distinguished by an ∼ 200 amino acid domain of unknown function, ROQ, that is highly conserved from mammals to invertebrates and is flanked by a RING-1 zinc finger and a CCCH zinc...[Show more]
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