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Chlamydia muridarum infection Subverts Dendritic Cell Function to promote Th2 Immunity and Airways Hyperreactivity

Kaiko, Gerard E; Phipps, Simon; Hickey, Danica K; Lam, Chuan En; Hansbro, Phil M; Foster, Paul S; Beagley, Kenneth W


There is strong epidemiological evidence that Chlamydia infection can lead to exacerbation of asthma. However, the mechanism(s) whereby chlamydial infection, which normally elicits a strong Th type 1 (Th1) immune response, can exacerbate asthma, a disease characterized by dominant Th type 2 (Th2) immune responses, remains unclear. In the present study, we show that Chlamydia muridarum infection of murine bone marrow-derived dendritic cells (BMDC) modulates the phenotype, cytokine secretion...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Journal of Immunology


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