Expansion of Circulating T Cells Resembling Follicular Helper T Cells Is a Fixed Phenotype That Identifies a Subset of Severe Systemic Lupus Erythematosus
Simpson, Nick; Gatenby, Paul; Wilson, Anastasia; Malik, Shreya; Fulcher, David; Tangye, Stuart; Manku, Harinder; Vyse, Timothy J; Roncador, Giovanna; Huttley, Gavin Austin; Goodnow, Christopher; Garcia De Vinuesa, Maria Carola; Cook, Matthew
Objective. In the sanroque mouse model of lupus, pathologic germinal centers (GCs) arise due to increased numbers of follicular helper T (Tfh) cells, resulting in high-affinity anti-double-stranded DNA antibodies that cause end-organ inflammation, such as glomerulonephritis. The purpose of this study was to examine the hypothesis that this pathway could account for a subset of patients with systemic lupus erythematosus (SLE). Methods. An expansion of Tfh cells is a causal, and therefore...[Show more]
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|Source:||Arthritis & Rheumatism|
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