Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance
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Chatzigeorgiou, Antonios; Seijkens, Tom; Zarzycka, Barbara; Engel, David; Poggi, Marjorie; van den Berg, Susan; van den Berg, Sjoerd; Soehnlein, Oliver; Winkels, Holger; Beckers, Linda; Schulte, Klaus-Martin
Description
The immune system plays an instrumental role in obesity and insulin resistance. Here, we unravel the role of the costimulatory molecule CD40 and its signaling intermediates, TNF receptor-associated factors (TRAFs), in diet-induced obesity (DIO). Although
Collections | ANU Research Publications |
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Date published: | 2014 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/35783 |
Source: | PNAS - Proceedings of the National Academy of Sciences of the United States of America |
DOI: | 10.1073/pnas.1400419111/-/DCSupplemental |
Access Rights: | Open Access |
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01_Chatzigeorgiou_Blocking_CD40-TRAF6_signaling_2014.pdf | 1.86 MB | Adobe PDF |
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