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Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance

Chatzigeorgiou, Antonios; Seijkens, Tom; Zarzycka, Barbara; Engel, David; Poggi, Marjorie; van den Berg, Susan; van den Berg, Sjoerd; Soehnlein, Oliver; Winkels, Holger; Beckers, Linda; Schulte, Klaus-Martin

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The immune system plays an instrumental role in obesity and insulin resistance. Here, we unravel the role of the costimulatory molecule CD40 and its signaling intermediates, TNF receptor-associated factors (TRAFs), in diet-induced obesity (DIO). Although

dc.contributor.authorChatzigeorgiou, Antonios
dc.contributor.authorSeijkens, Tom
dc.contributor.authorZarzycka, Barbara
dc.contributor.authorEngel, David
dc.contributor.authorPoggi, Marjorie
dc.contributor.authorvan den Berg, Susan
dc.contributor.authorvan den Berg, Sjoerd
dc.contributor.authorSoehnlein, Oliver
dc.contributor.authorWinkels, Holger
dc.contributor.authorBeckers, Linda
dc.contributor.authorSchulte, Klaus-Martin
dc.date.accessioned2015-12-08T22:38:03Z
dc.identifier.issn0027-8424
dc.identifier.urihttp://hdl.handle.net/1885/35783
dc.description.abstractThe immune system plays an instrumental role in obesity and insulin resistance. Here, we unravel the role of the costimulatory molecule CD40 and its signaling intermediates, TNF receptor-associated factors (TRAFs), in diet-induced obesity (DIO). Although
dc.publisherNational Academy of Sciences (USA)
dc.rightsAuthor/s retain copyright
dc.sourcePNAS - Proceedings of the National Academy of Sciences of the United States of America
dc.titleBlocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume111
dc.date.issued2014
local.identifier.absfor110323 - Surgery
local.identifier.ariespublicationu4425841xPUB128
local.type.statusPublished Version
local.contributor.affiliationChatzigeorgiou, Antonios, Department of Clinical Pathobiochemistry
local.contributor.affiliationSeijkens, Tom, Department of Medical Biochemistry, Subdivision of Experimental Vascular Biology, Academic Medical Center
local.contributor.affiliationZarzycka, Barbara, Department of Biochemistry
local.contributor.affiliationEngel, David, Department of Pathology
local.contributor.affiliationPoggi, Marjorie, Department of Pathology
local.contributor.affiliationvan den Berg, Susan, Department of Medical Biochemistry,Subdivision of Experimental Vascular Biology, Academic Medical Center
local.contributor.affiliationvan den Berg, Sjoerd, Department of Human Genetics
local.contributor.affiliationSoehnlein, Oliver, Department of Pathology, Academic Medical Center
local.contributor.affiliationWinkels, Holger, Institute for Cardiovascular Prevention
local.contributor.affiliationBeckers, Linda, Department of Medical Biochemistry, Subdivision of Experimental Vascular Biology, Academic Medical Center
local.contributor.affiliationSchulte, Klaus-Martin, College of Medicine, Biology and Environment, ANU
local.bibliographicCitation.issue7
local.bibliographicCitation.startpage2686
local.bibliographicCitation.lastpage2691
local.identifier.doi10.1073/pnas.1400419111/-/DCSupplemental
dc.date.updated2015-12-08T10:05:27Z
local.identifier.scopusID2-s2.0-84894377101
dcterms.accessRightsOpen Access
CollectionsANU Research Publications

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