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Brief exposure to damaging light causes focal recruitment of macrophages, and long-term destabilization of photoreceptors in the albino rat retina

Rutar, Matthew; Provis, Jan; Valter (Valter-Kocsi), Krisztina


Purpose: To characterize the long-term spatiotemporal features of light-mediated retinal degeneration. Methods: SpragueDawley rats were exposed to 1000 lux for 24h, then kept in dim light (5 lux), for up to 56 days. Animals were killed at 0, 3, 7, 28, and 56 days post-exposure, and retinas were prepared for immunohistochemistry. Outer nuclear layer (ONL) thickness and TUNEL labeling were used to quantify photoreceptor death. Antibodies to opsins, glial fibrillary acidic protein (GFAP),...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Current Eye Research
DOI: 10.3109/02713681003682925


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