BDNF Exerts Contrasting Effects on Peripheral Myelination of NGF-Dependent and BDNF-Dependent DRG Neurons
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Xiao, Junhua; Wong, Agnes W; Willingham, Melanie M; Kaasinen, Selma; Hendry, Ian; Howitt, Jason; Putz, Ulrich; Barrett, Graham L; Kilpatrick, Trevor J; Murray, Simon S
Description
Although brain-derived neurotrophic factor (BDNF) has been shown to promote peripheral myelination during development and remy-elination after injury, the precise mechanisms mediating this effect remain unknown. Here, we determine that BDNF promotes myelination of nerve growth factor-dependent neurons, an effect dependent on neuronal expression of the p75 neurotrophin receptor, whereas BDNF inhibits myelination of BDNF-dependent neurons via the full-length TrkB receptor. Thus, BDNF exerts...[Show more]
Collections | ANU Research Publications |
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Date published: | 2009 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/35718 |
Source: | Journal of Neuroscience |
DOI: | 10.1523/JNEUROSCI.3811-08.2009 |
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01_Xiao_BDNF_Exerts_Contrasting_2009.pdf | 974.55 kB | Adobe PDF | ![]() |
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