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Cortical Morphometric Subclassification of Frontotemporal Lobar Degeneration

Lindberg, Olof; Ostberg, P; Zandbelt, B.B.; Oberg, J; Zhang, Yi; Anderson, C; Looi, Jeffrey; Bogdanovic, N; Wahlund, Lars-Olof

Description

BACKGROUND AND PURPOSE: Frontotemporal lobar degeneration (FTLD) is a primary neurodegenerative disease comprising 3 clinical subtypes: frontotemporal dementia (FTD), semantic dementia (SD), and progressive nonfluent aphasia (PNFA). The subdivision is primarily based on the characteristic clinical symptoms displayed by each subtype. We hypothesized that these symptoms would be correlated to characteristic patterns of brain atrophy, which could be indentified and used for subclassification of...[Show more]

dc.contributor.authorLindberg, Olof
dc.contributor.authorOstberg, P
dc.contributor.authorZandbelt, B.B.
dc.contributor.authorOberg, J
dc.contributor.authorZhang, Yi
dc.contributor.authorAnderson, C
dc.contributor.authorLooi, Jeffrey
dc.contributor.authorBogdanovic, N
dc.contributor.authorWahlund, Lars-Olof
dc.date.accessioned2015-12-08T22:37:50Z
dc.identifier.issn0195-6108
dc.identifier.urihttp://hdl.handle.net/1885/35683
dc.description.abstractBACKGROUND AND PURPOSE: Frontotemporal lobar degeneration (FTLD) is a primary neurodegenerative disease comprising 3 clinical subtypes: frontotemporal dementia (FTD), semantic dementia (SD), and progressive nonfluent aphasia (PNFA). The subdivision is primarily based on the characteristic clinical symptoms displayed by each subtype. We hypothesized that these symptoms would be correlated to characteristic patterns of brain atrophy, which could be indentified and used for subclassification of subjects with FTLD. MATERIALS AND METHODS: Volumes of 9 cortical regions were manually parcellated and measured on both hemispheres on 27 controls, 12 patients with FTD, 9 patients with PNFA, and 13 patients with SD. The volumetric data were analyzed by traditional t tests and by a multivariate discriminant analysis (partial least squares discriminant analysis). RESULTS: The ensemble or pattern of atrophy was a good discriminator in pair-wise comparison between the subtypes: FTD compared with SD (sensitivity 100% [12/12], specificity 100% [13/13]); FTD compared with PNFA (sensitivity 92% [11/12], specificity 89% [8/9]); and SD compared with PNFA (sensitivity 86% [11/13], specificity 100% [9/9]). Temporal-versus-frontal atrophy was the most important pattern for discriminating SD from the other 2 subtypes. Right-sided versus left-sided atrophy was the most important pattern for discriminating between subjects with FTD and PNFA. CONCLUSIONS: FTLD subtypes generally display a characteristic pattern of atrophy, which may be considered in diagnosing patients with FTLD.
dc.publisherAmerican Society of Neuroradiology
dc.sourceAmerican Journal of Neuroradiology
dc.subjectKeywords: adult; aged; article; brain atrophy; brain cortex; brain size; clinical article; controlled study; diagnostic accuracy; discriminant analysis; disease classification; disease duration; female; frontotemporal dementia; human; image analysis; male; mini men
dc.titleCortical Morphometric Subclassification of Frontotemporal Lobar Degeneration
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume30
dc.date.issued2009
local.identifier.absfor110319 - Psychiatry (incl. Psychotherapy)
local.identifier.ariespublicationu4201517xPUB127
local.type.statusPublished Version
local.contributor.affiliationLindberg, Olof, Karolinska Institute
local.contributor.affiliationOstberg, P, Karolinska Institute
local.contributor.affiliationZandbelt, B.B., Karolinska Institute
local.contributor.affiliationOberg, J, Karolinska Institute
local.contributor.affiliationZhang, Yi, Karolinska University Hospital
local.contributor.affiliationAnderson, C, Karolinska Institute
local.contributor.affiliationLooi, Jeffrey, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationBogdanovic, N, Karolinska Institute
local.contributor.affiliationWahlund, Lars-Olof, Karolinska Institute
local.description.embargo2037-12-31
local.bibliographicCitation.startpage1233
local.bibliographicCitation.lastpage1239
local.identifier.doi10.3174/ajnr.A1545
dc.date.updated2016-02-24T10:40:37Z
local.identifier.scopusID2-s2.0-67449132613
local.identifier.thomsonID000267258400028
CollectionsANU Research Publications

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