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Demyelination caused by the copper chelator cuprizone halts T cell mediated autoimmune neuroinflammation

Mana, Paula; Fordham, Susan; Staykova, Maria; Correcha, Manuel; Silva, Diego; Willenborg, D; Linares, David


Myelin reactive T cells are central in the development of the autoimmune response leading to CNS destruction in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis (EAE). Investigations on the mechanisms underlying the activation and expansion of myelin reactive T have stressed the importance of non-autoimmune conditions impinging the autoimmune repertoire potentially involved in the disease. Here, we show that CNS injury caused by the toxic cuprizone results in the generation of...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Journal of Neuroimmunology
DOI: 10.1016/j.jneuroim.2009.02.013


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