Skip navigation
Skip navigation

Putaminal Volume in Frontotemporal Lobar Degeneration and Alzheimer Disease: Differential Volumes in Dementia Subtypes and Controls

Looi, Jeffrey; Svensson, Leif; Lindberg, Olof; Zandbelt, B.B.; Ostberg, P; Orndahl, E; Wahlund, Lars-Olof

Description

BACKGROUND AND PURPOSE: Frontostriatal (including the putamen) circuit-mediated cognitive dysfunction has been implicated in frontotemporal lobar degeneration (FTLD), but not in Alzheimer disease (AD) or healthy aging. We sought to assess putaminal volume as a measure of the structural basis of relative frontostriatal dysfunction in these groups. MATERIALS AND METHODS: We measured putaminal volume in FTLD subtypes: frontotemporal dementia (FTD, n = 12), semantic dementia (SD, n = 13), and...[Show more]

dc.contributor.authorLooi, Jeffrey
dc.contributor.authorSvensson, Leif
dc.contributor.authorLindberg, Olof
dc.contributor.authorZandbelt, B.B.
dc.contributor.authorOstberg, P
dc.contributor.authorOrndahl, E
dc.contributor.authorWahlund, Lars-Olof
dc.date.accessioned2015-12-08T22:37:24Z
dc.identifier.issn0195-6108
dc.identifier.urihttp://hdl.handle.net/1885/35510
dc.description.abstractBACKGROUND AND PURPOSE: Frontostriatal (including the putamen) circuit-mediated cognitive dysfunction has been implicated in frontotemporal lobar degeneration (FTLD), but not in Alzheimer disease (AD) or healthy aging. We sought to assess putaminal volume as a measure of the structural basis of relative frontostriatal dysfunction in these groups. MATERIALS AND METHODS: We measured putaminal volume in FTLD subtypes: frontotemporal dementia (FTD, n = 12), semantic dementia (SD, n = 13), and progressive nonfluent aphasia (PNFA, n = 9) in comparison with healthy controls (n = 25) and patients with AD (n = 18). Diagnoses were based on accepted clinical criteria. We conducted manual volume measurement of the putamen blinded to the diagnosis on T1 brain MR imaging by using a standardized protocol. RESULTS: Paired t tests (P < .05) showed that the left putaminal volume was significantly larger than the right in all groups combined. Multivariate analysis of covariance with a Bonferroni correction was used to assess statistical significance among the subject groups (AD, FTD, SD, PNFA, and controls) as independent variables and right/left putaminal volumes as dependent variables (covariates, age and intracranial volume; P < .05). The right putamen in FTD was significantly smaller than in AD and controls; whereas in SD, it was smaller compared with controls with a trend toward being smaller than in AD. There was also a trend toward the putamen in the PNFA being smaller than that in controls and in patients with AD. Across the groups, there was a positive partial correlation between putaminal volume and Mini-Mental State Examination (MMSE). CONCLUSIONS: Right putaminal volume was significantly smaller in FTD, the FTLD subtype with the greatest expected frontostriatal dysfunction; whereas in SD and PNFA, it showed a trend towards being smaller, consistent with expectation, compared to controls and AD; and in SD, compared with AD and controls. Putaminal volume weakly correlated with MMSE.
dc.publisherAmerican Society of Neuroradiology
dc.sourceAmerican Journal of Neuroradiology
dc.subjectKeywords: adult; aged; Alzheimer disease; article; brain dysfunction; brain size; cognition; controlled study; corpus striatum; female; frontal cortex; frontotemporal dementia; hemisphere; human; major clinical study; male; mini mental state examination; nuclear ma
dc.titlePutaminal Volume in Frontotemporal Lobar Degeneration and Alzheimer Disease: Differential Volumes in Dementia Subtypes and Controls
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume30
dc.date.issued2009
local.identifier.absfor110319 - Psychiatry (incl. Psychotherapy)
local.identifier.ariespublicationu4201517xPUB125
local.type.statusPublished Version
local.contributor.affiliationLooi, Jeffrey, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationSvensson, Leif, Karolinska University Hospital
local.contributor.affiliationLindberg, Olof, Karolinska Institute
local.contributor.affiliationZandbelt, B.B., Karolinska Institute
local.contributor.affiliationOstberg, P, Karolinska Institute
local.contributor.affiliationOrndahl, E, Karolinska Institute
local.contributor.affiliationWahlund, Lars-Olof, Karolinska Institute
local.description.embargo2037-12-31
local.bibliographicCitation.startpage1552
local.bibliographicCitation.lastpage1560
local.identifier.doi10.3174/ajnr.A1640
dc.date.updated2016-02-24T10:40:36Z
local.identifier.scopusID2-s2.0-70349206042
local.identifier.thomsonID000270004200020
CollectionsANU Research Publications

Download

File Description SizeFormat Image
01_Looi_Putaminal_Volume_in_2009.pdf28.35 kBAdobe PDF    Request a copy
02_Looi_Putaminal_Volume_in_2009.pdf214.23 kBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator