Putaminal Volume in Frontotemporal Lobar Degeneration and Alzheimer Disease: Differential Volumes in Dementia Subtypes and Controls
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Looi, Jeffrey; Svensson, Leif; Lindberg, Olof; Zandbelt, B.B.; Ostberg, P; Orndahl, E; Wahlund, Lars-Olof
Description
BACKGROUND AND PURPOSE: Frontostriatal (including the putamen) circuit-mediated cognitive dysfunction has been implicated in frontotemporal lobar degeneration (FTLD), but not in Alzheimer disease (AD) or healthy aging. We sought to assess putaminal volume as a measure of the structural basis of relative frontostriatal dysfunction in these groups. MATERIALS AND METHODS: We measured putaminal volume in FTLD subtypes: frontotemporal dementia (FTD, n = 12), semantic dementia (SD, n = 13), and...[Show more]
dc.contributor.author | Looi, Jeffrey | |
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dc.contributor.author | Svensson, Leif | |
dc.contributor.author | Lindberg, Olof | |
dc.contributor.author | Zandbelt, B.B. | |
dc.contributor.author | Ostberg, P | |
dc.contributor.author | Orndahl, E | |
dc.contributor.author | Wahlund, Lars-Olof | |
dc.date.accessioned | 2015-12-08T22:37:24Z | |
dc.identifier.issn | 0195-6108 | |
dc.identifier.uri | http://hdl.handle.net/1885/35510 | |
dc.description.abstract | BACKGROUND AND PURPOSE: Frontostriatal (including the putamen) circuit-mediated cognitive dysfunction has been implicated in frontotemporal lobar degeneration (FTLD), but not in Alzheimer disease (AD) or healthy aging. We sought to assess putaminal volume as a measure of the structural basis of relative frontostriatal dysfunction in these groups. MATERIALS AND METHODS: We measured putaminal volume in FTLD subtypes: frontotemporal dementia (FTD, n = 12), semantic dementia (SD, n = 13), and progressive nonfluent aphasia (PNFA, n = 9) in comparison with healthy controls (n = 25) and patients with AD (n = 18). Diagnoses were based on accepted clinical criteria. We conducted manual volume measurement of the putamen blinded to the diagnosis on T1 brain MR imaging by using a standardized protocol. RESULTS: Paired t tests (P < .05) showed that the left putaminal volume was significantly larger than the right in all groups combined. Multivariate analysis of covariance with a Bonferroni correction was used to assess statistical significance among the subject groups (AD, FTD, SD, PNFA, and controls) as independent variables and right/left putaminal volumes as dependent variables (covariates, age and intracranial volume; P < .05). The right putamen in FTD was significantly smaller than in AD and controls; whereas in SD, it was smaller compared with controls with a trend toward being smaller than in AD. There was also a trend toward the putamen in the PNFA being smaller than that in controls and in patients with AD. Across the groups, there was a positive partial correlation between putaminal volume and Mini-Mental State Examination (MMSE). CONCLUSIONS: Right putaminal volume was significantly smaller in FTD, the FTLD subtype with the greatest expected frontostriatal dysfunction; whereas in SD and PNFA, it showed a trend towards being smaller, consistent with expectation, compared to controls and AD; and in SD, compared with AD and controls. Putaminal volume weakly correlated with MMSE. | |
dc.publisher | American Society of Neuroradiology | |
dc.source | American Journal of Neuroradiology | |
dc.subject | Keywords: adult; aged; Alzheimer disease; article; brain dysfunction; brain size; cognition; controlled study; corpus striatum; female; frontal cortex; frontotemporal dementia; hemisphere; human; major clinical study; male; mini mental state examination; nuclear ma | |
dc.title | Putaminal Volume in Frontotemporal Lobar Degeneration and Alzheimer Disease: Differential Volumes in Dementia Subtypes and Controls | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 30 | |
dc.date.issued | 2009 | |
local.identifier.absfor | 110319 - Psychiatry (incl. Psychotherapy) | |
local.identifier.ariespublication | u4201517xPUB125 | |
local.type.status | Published Version | |
local.contributor.affiliation | Looi, Jeffrey, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Svensson, Leif, Karolinska University Hospital | |
local.contributor.affiliation | Lindberg, Olof, Karolinska Institute | |
local.contributor.affiliation | Zandbelt, B.B., Karolinska Institute | |
local.contributor.affiliation | Ostberg, P, Karolinska Institute | |
local.contributor.affiliation | Orndahl, E, Karolinska Institute | |
local.contributor.affiliation | Wahlund, Lars-Olof, Karolinska Institute | |
local.description.embargo | 2037-12-31 | |
local.bibliographicCitation.startpage | 1552 | |
local.bibliographicCitation.lastpage | 1560 | |
local.identifier.doi | 10.3174/ajnr.A1640 | |
dc.date.updated | 2016-02-24T10:40:36Z | |
local.identifier.scopusID | 2-s2.0-70349206042 | |
local.identifier.thomsonID | 000270004200020 | |
Collections | ANU Research Publications |
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