Redefinition of rubisco carboxylase reaction reveals origin of water for hydration and new roles for active-site residues
Crystallographic, mutagenesis, kinetic, and computational studies on Rubisco over three decades have revealed much about its catalytic mechanism and the role played by several active-site residues. However, key questions remain unanswered. Specific details of the carboxylase and oxygenase mechanisms, required to underpin the rational re-engineering of Rubisco, are still speculative. Here we address critical gaps in knowledge with a definitive comprehensive computational investigation of the...[Show more]
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|Source:||Journal of the American Chemical Society|
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