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Cellular immunity before and after leptin replacement therapy

Da Paz Filho, Gilberto; Delibasi, Tuncay; Erol, Halil Kutlu; Wong, Ma-Li; Licinio, Julio

Description

Background: The few identified leptin-deficient children have immune deficiency. Aims: To evaluate whether a newly-identified leptin-deficient boy has immune defects; to assess the immune changes during leptin replacement. Methods: A 5 year-old boy with congenital leptin deficiency was evaluated before, 2 weeks and 6 weeks after the initiation of recombinant methionyl human leptin. Thymic volume was measured by computed tomography. Humoral immunity was assessed by measuring levels of several...[Show more]

dc.contributor.authorDa Paz Filho, Gilberto
dc.contributor.authorDelibasi, Tuncay
dc.contributor.authorErol, Halil Kutlu
dc.contributor.authorWong, Ma-Li
dc.contributor.authorLicinio, Julio
dc.date.accessioned2015-12-08T22:36:05Z
dc.identifier.issn0334-018X
dc.identifier.urihttp://hdl.handle.net/1885/35104
dc.description.abstractBackground: The few identified leptin-deficient children have immune deficiency. Aims: To evaluate whether a newly-identified leptin-deficient boy has immune defects; to assess the immune changes during leptin replacement. Methods: A 5 year-old boy with congenital leptin deficiency was evaluated before, 2 weeks and 6 weeks after the initiation of recombinant methionyl human leptin. Thymic volume was measured by computed tomography. Humoral immunity was assessed by measuring levels of several immunoglobulins. Cellular immunity was evaluated by the analysis of lymphocyte proliferation in response to mitogens. Lymphocyte subsets were quantified by flow cytometry. Results: At baseline, thymic volume was increased. The lymphocyte subsets count and humoral/cellular immunities were normal. After treatment, proliferative response to mitogens increased by 1.5- to 3-fold, and lymphocyte count decreased by 17%. Conclusions: Immune defects are not an obligatory feature of congenital leptin deficiency. Even in the absence of significant immune defects, leptin replacement therapy enhanced T-cell responsiveness.
dc.publisherFreund Publishing House Ltd
dc.sourceJournal of Pediatric Endocrinology and Metabolism
dc.subjectKeywords: bacterial antigen; concanavalin A; immunoglobulin A; immunoglobulin E; immunoglobulin G; immunoglobulin M; phytohemagglutinin; pokeweed mitogen; recombinant leptin; antibody response; article; case report; cellular immunity; child; computer assisted tomog Deficiency; Immunity; Leptin; Obesity; T cell
dc.titleCellular immunity before and after leptin replacement therapy
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume22
dc.date.issued2009
local.identifier.absfor110306 - Endocrinology
local.identifier.absfor111403 - Paediatrics
local.identifier.absfor110107 - Metabolic Medicine
local.identifier.ariespublicationu6800332xPUB120
local.type.statusPublished Version
local.contributor.affiliationDa Paz Filho, Gilberto, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationDelibasi, Tuncay, University of Miami
local.contributor.affiliationErol, Halil Kutlu, University of Miami
local.contributor.affiliationWong, Ma-Li, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationLicinio, Julio, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue11
local.bibliographicCitation.startpage1
local.bibliographicCitation.lastpage11
dc.date.updated2016-02-24T11:37:42Z
local.identifier.scopusID2-s2.0-75749150169
CollectionsANU Research Publications

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