Cellular immunity before and after leptin replacement therapy
Background: The few identified leptin-deficient children have immune deficiency. Aims: To evaluate whether a newly-identified leptin-deficient boy has immune defects; to assess the immune changes during leptin replacement. Methods: A 5 year-old boy with congenital leptin deficiency was evaluated before, 2 weeks and 6 weeks after the initiation of recombinant methionyl human leptin. Thymic volume was measured by computed tomography. Humoral immunity was assessed by measuring levels of several...[Show more]
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|Source:||Journal of Pediatric Endocrinology and Metabolism|
|01_Da Paz Filho_Cellular_immunity_before_and_2009.pdf||105.29 kB||Adobe PDF||Request a copy|
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