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Polar residues in a conserved motif spanning helices 1 and 2 are functionally important in the SulP transporter family

Leves, Fiona; Tierney, Mary (Louise); Howitt, Susan

Description

The SulP family (including the SLC26 family) is a diverse family of anion transporters found in all domains of life, with different members transporting different anions. We used sequence and bioinformatics analysis of helices 1 and 2 of SulP family members to identify a conserved motif, extending the previously defined 'sulfate transporter motif'. The analysis showed that in addition to being highly conserved in both sequence and spacing, helices 1 and 2 contain a significant number of polar...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
URI: http://hdl.handle.net/1885/35054
Source: The International Journal of Biochemistry and Cell Biology
DOI: 10.1016/j.biocel.2008.05.007

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