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Delineation of precursors in murine spleen that develop in contact with splenic endothelium to give novel dendritic-like cells

Tan, Jonathan; Periasamy, Pravin; O'Neill, Helen

Description

Hematopoietic cell lineages are best described in terms of distinct progenitors with limited differentiative capacity. To distinguish cell lineages, it is necessary to define progenitors and induce their differentiation in vitro. We previously reported in vitro development of immature dendritic-like cells (DCs) in long-term cultures (LTCs) of murine spleen, and in cocultures of spleen or bone marrow (BM) over splenic endothelial cell lines derived from LTCs. Cells produced are phenotypically...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
URI: http://hdl.handle.net/1885/35022
Source: Blood
DOI: 10.1182/blood-2009-06-227108

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