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Regulation of histidine-rich glycoprotein (HRG) function via plasmin-mediated proteolytic cleavage

Poon, Ivan; Olsson, Anna-Karin; Hulett, Mark; Parish, Christopher


The plasminogen/plasmin system is involved in a variety of normal physiological and pathological processes, including tissue remodelling, angiogenesis and tumour metastasis. Plasminogen activators and receptors for plasminogen/plasminogen activators are essential for the processing of plasminogen to form the active serine protease plasmin. Plasmin can in turn positively or negatively regulate further plasminogen activation via plasmin-mediated cleavage of receptors and activators. HRG...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Biochemical Journal
DOI: 10.1042/BJ20090794


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