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Interleukin-21 is required for the development of Type 1 Diabetes in NOD mice

Sutherland, Andrew; Van Belle, Tom; Wurster, Andrea L.; Suto, Akira; Michaud, Monia; Zhang, Dorothy; Grusby, Michael J.; von Herrath, Matthias


OBJECTIVE- Interleukin (IL)-21 is a type 1 cytokine that has been implicated in the pathogenesis of type 1 diabetes via the unique biology of the nonobese diabetic (NOD) mouse strain. The aim of this study was to investigate a causal role for IL-21 in type 1 diabetes. RESEARCH DESIGN AND METHODS- We generated IL- 21R-deficient NOD mice and C57Bl/6 mice expressing IL-21 in pancreatic β-cells, allowing the determination of the role of insufficient and excessive IL-21 signaling in type 1 diabetes....[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Diabetes
DOI: 10.2337/db08-0882


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