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Citrus polymethoxylated flavones improve lipid and glucose homeostasis and modulate adipocytokines in fructose-induced insulin resistant hamsters

Li, Rachel; Theriault, A G; Au, Karen; Douglas, Teresa D; Casaschi, A; Kurowska, Elzbieta M; Mukherjee, Rinee

Description

The present study was undertaken to determine whether supplementation with polymethoxylated flavones (PMFs) could ameliorate the fructose-induced hypertriglyceridemia and other metabolic abnormalities associated with insulin resistance (IR) in hamsters. Following feeding with the fructose diet, hamsters were supplemented orally with PMF-L or PMF-H (62.5 and 125 mg/kg/day) for 4 weeks. Both PMF-treated groups showed a statistically significant (p < 0.05) decrease in serum triglyceride (TG) and...[Show more]

dc.contributor.authorLi, Rachel
dc.contributor.authorTheriault, A G
dc.contributor.authorAu, Karen
dc.contributor.authorDouglas, Teresa D
dc.contributor.authorCasaschi, A
dc.contributor.authorKurowska, Elzbieta M
dc.contributor.authorMukherjee, Rinee
dc.date.accessioned2015-12-08T22:34:01Z
dc.identifier.issn0024-3205
dc.identifier.urihttp://hdl.handle.net/1885/34892
dc.description.abstractThe present study was undertaken to determine whether supplementation with polymethoxylated flavones (PMFs) could ameliorate the fructose-induced hypertriglyceridemia and other metabolic abnormalities associated with insulin resistance (IR) in hamsters. Following feeding with the fructose diet, hamsters were supplemented orally with PMF-L or PMF-H (62.5 and 125 mg/kg/day) for 4 weeks. Both PMF-treated groups showed a statistically significant (p < 0.05) decrease in serum triglyceride (TG) and cholesterol levels compared to the fructose-fed control group. The fructose control group at the end of the study showed elevated serum insulin and impaired insulin sensitivity (glucose intolerance). On the other hand, PMF-supplemented groups showed a reversal in these metabolic defects, including a decrease in insulin level and an improvement in glucose tolerance. PMF supplementation also reduced TG contents in the liver and heart and was able to regulate adipocytokines by significantly suppressing TNF-α, INF-γ, IL-1β and IL-6 expression and increasing adiponectin in IR hamsters. The mechanism of PMF on the activation of peroxisome proliferator-activated receptors (PPAR) was also explored. PMF-H supplementation significantly increased PPARα and PPARγ protein expression in the liver. This is the first report of positive effects of PMF on adipocytokine production and on PPAR expression in IR hamsters. This study suggests that PMF can ameliorate hypertriglyceridemia and its anti-diabetic effects may occur as a consequence of adipocytokine regulation and PPARα and PPARγ activation.
dc.publisherElsevier
dc.sourceLife Sciences
dc.subjectKeywords: adipocytokine; adiponectin; cholesterol; flavone derivative; fructose; gamma interferon; glucose; insulin; interleukin 1beta; interleukin 6; lipid; peroxisome proliferator activated receptor alpha; peroxisome proliferator activated receptor gamma; triacyl Adipocytokines; Insulin resistance; Peroxisome proliferator-activated receptor; Polymethoxylated flavones; Triglyceride
dc.titleCitrus polymethoxylated flavones improve lipid and glucose homeostasis and modulate adipocytokines in fructose-induced insulin resistant hamsters
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume79
dc.date.issued2006
local.identifier.absfor060802 - Animal Cell and Molecular Biology
local.identifier.ariespublicationu4133361xPUB118
local.type.statusPublished Version
local.contributor.affiliationLi, Rachel, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationTheriault, A G, University of Hawaii
local.contributor.affiliationAu, Karen, KGK Synergize Inc.
local.contributor.affiliationDouglas, Teresa D, University of Hawaii
local.contributor.affiliationCasaschi, A, University of Hawaii
local.contributor.affiliationKurowska, Elzbieta M, KGK Synergize Inc.
local.contributor.affiliationMukherjee, Rinee, KGK Synergize Inc.
local.description.embargo2037-12-31
local.bibliographicCitation.issue4
local.bibliographicCitation.startpage365
local.bibliographicCitation.lastpage373
local.identifier.doi10.1016/j.lfs.2006.01.023
dc.date.updated2015-12-08T09:39:52Z
local.identifier.scopusID2-s2.0-33745769794
CollectionsANU Research Publications

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