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Deletion of Glu155 causes a deficiency of glutathione transferase Omega 1-1 but does not alter sensitivity to arsenic trioxide and other cytotoxic drugs

Schmuck, Erica; Cappello, Jean; Coggan, Marjorie; Brew, Jennifer; Cavanaugh, Juleen; Blackburn, Anneke; Baker, Rohan; Eyre, Helen; Sutherland, Grant; Board, Philip

Description

The Omega class glutathione transferase GSTO1-1 can catalyze the reduction of pentavalent methylated arsenic species and is responsible for the biotransfomation of potentially toxic α-haloketones. We investigated the cause of GSTO1-1 deficiency in the T-

dc.contributor.authorSchmuck, Erica
dc.contributor.authorCappello, Jean
dc.contributor.authorCoggan, Marjorie
dc.contributor.authorBrew, Jennifer
dc.contributor.authorCavanaugh, Juleen
dc.contributor.authorBlackburn, Anneke
dc.contributor.authorBaker, Rohan
dc.contributor.authorEyre, Helen
dc.contributor.authorSutherland, Grant
dc.contributor.authorBoard, Philip
dc.date.accessioned2015-12-08T22:34:00Z
dc.identifier.issn1357-2725
dc.identifier.urihttp://hdl.handle.net/1885/34882
dc.description.abstractThe Omega class glutathione transferase GSTO1-1 can catalyze the reduction of pentavalent methylated arsenic species and is responsible for the biotransfomation of potentially toxic α-haloketones. We investigated the cause of GSTO1-1 deficiency in the T-
dc.publisherPergamon-Elsevier Ltd
dc.sourceThe International Journal of Biochemistry and Cell Biology
dc.subjectKeywords: 4 nitrophenacylglutathione; arsenic trioxide; cisplatin; cytotoxic agent; daunorubicin; doxorubicin; etoposide; glutathione derivative; glutathione transferase; glutathione transferase omega 1 1; messenger RNA; unclassified drug; article; breast cancer; c Arsenic biotransformation; Drug resistance; Glutathione transferase Omega; Glutatione transferase deficiency; GSTO1-1
dc.titleDeletion of Glu155 causes a deficiency of glutathione transferase Omega 1-1 but does not alter sensitivity to arsenic trioxide and other cytotoxic drugs
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume40
dc.date.issued2008
local.identifier.absfor060404 - Epigenetics (incl. Genome Methylation and Epigenomics)
local.identifier.absfor010399 - Numerical and Computational Mathematics not elsewhere classified
local.identifier.ariespublicationu4020362xPUB118
local.type.statusPublished Version
local.contributor.affiliationSchmuck, Erica, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationCappello, Jean, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationCoggan, Marjorie, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationBrew, Jennifer, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationCavanaugh, Juleen, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationBlackburn, Anneke, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationBaker, Rohan, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationEyre, Helen, Women's and Children's Hospital
local.contributor.affiliationSutherland, Grant, Women's and Children's Hospital
local.contributor.affiliationBoard, Philip, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue11
local.bibliographicCitation.startpage2553
local.bibliographicCitation.lastpage9
local.identifier.doi10.1016/j.biocel.2008.04.017
dc.date.updated2015-12-08T09:39:43Z
local.identifier.scopusID2-s2.0-48349093748
local.identifier.thomsonID000259134100025
CollectionsANU Research Publications

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