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Deletion of Glu155 causes a deficiency of glutathione transferase Omega 1-1 but does not alter sensitivity to arsenic trioxide and other cytotoxic drugs

Schmuck, Erica; Cappello, Jean; Coggan, Marjorie; Brew, Jennifer; Cavanaugh, Juleen; Blackburn, Anneke; Baker, Rohan; Eyre, Helen; Sutherland, Grant; Board, Philip

Description

The Omega class glutathione transferase GSTO1-1 can catalyze the reduction of pentavalent methylated arsenic species and is responsible for the biotransfomation of potentially toxic α-haloketones. We investigated the cause of GSTO1-1 deficiency in the T-

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
URI: http://hdl.handle.net/1885/34882
Source: The International Journal of Biochemistry and Cell Biology
DOI: 10.1016/j.biocel.2008.04.017

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