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Remote hindlimb preconditioning and hepatoprotection: NO-table strides against liver ischaemia/reperfusion injury

Teoh, Narcissus

Description

Hepatic IR (ischaemia/reperfusion) injury is an important clinical problem complicating liver surgery and transplantation. IPC (ischaemic preconditioning) is a strategy whereby brief episodes of IR in an organ can induce an adaptive response to protect against subsequent prolonged IR injury. However, trauma to vessels supplying the target organ is unavoidable using the technique of direct IPC. One amenable strategy would be to apply the protective preconditioning stimulus to an organ distant or...[Show more]

dc.contributor.authorTeoh, Narcissus
dc.date.accessioned2015-12-08T22:33:51Z
dc.identifier.issn0143-5221
dc.identifier.urihttp://hdl.handle.net/1885/34832
dc.description.abstractHepatic IR (ischaemia/reperfusion) injury is an important clinical problem complicating liver surgery and transplantation. IPC (ischaemic preconditioning) is a strategy whereby brief episodes of IR in an organ can induce an adaptive response to protect against subsequent prolonged IR injury. However, trauma to vessels supplying the target organ is unavoidable using the technique of direct IPC. One amenable strategy would be to apply the protective preconditioning stimulus to an organ distant or remote from the target organ of interest, a technique known as RIPC (remote IPC). In the present issue of Clinical Science, Abu-Amara and co-workers utilize hindlimb RIPC as a novel therapeutic strategy against liver IR injury and investigate the mechanistic contribution of NO to hepatoprotection by administering C-PTIO [2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide potassium salt], an NO scavenger. Their experiments set the stage for more definitive studies to demonstrate a discernible benefit for the utility of RIPC in liver surgery and transplantation.
dc.publisherPortland Press
dc.sourceClinical Science
dc.subjectKeywords: 2 (4 carboxyphenyl) 4,4,5,5 tetramethylimidazoline 1 oxyl 3 oxide; adenosine; alanine aminotransferase; aspartate aminotransferase; cyclic GMP dependent protein kinase; endothelial nitric oxide synthase; guanylate cyclase; mitogen activated protein kinase Ischaemia/reperfusion; Ischaemic preconditioning; Liver; Nitric oxide; Reperfusion injury; Warm ischaemia
dc.titleRemote hindlimb preconditioning and hepatoprotection: NO-table strides against liver ischaemia/reperfusion injury
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume121
dc.date.issued2011
local.identifier.absfor110307 - Gastroenterology and Hepatology
local.identifier.ariespublicationu4971216xPUB117
local.type.statusPublished Version
local.contributor.affiliationTeoh, Narcissus, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue6
local.bibliographicCitation.startpage253
local.bibliographicCitation.lastpage255
local.identifier.doi10.1042/CS20110243
local.identifier.absseo970111 - Expanding Knowledge in the Medical and Health Sciences
dc.date.updated2016-02-24T11:31:10Z
local.identifier.scopusID2-s2.0-79961146430
local.identifier.thomsonID000295106200006
CollectionsANU Research Publications

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