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A dihydropyridine receptor alpha(1s) loop region critical for skeletal muscle contraction is intrinsically unstructured and binds to a SPRY domain of the type 1 ryanodine receptor

Cui, Yan Fang; Tae, Han Shen; Norris, Nicole; Karunasekara, Yamuna; Pouliquin, Pierre; Board, Philip; Dulhunty, Angela; Casarotto, Marco

Description

The II-III loop of the dihydropyridine receptor (DHPR) α1s subunit is a modulator of the ryanodine receptor (RyR1) Ca2+ release channel in vitro and is essential for skeletal muscle contraction in vivo. Despite its importance, the structure of this loop

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/34788
Source: The International Journal of Biochemistry and Cell Biology
DOI: 10.1016/j.biocel.2008.08.004

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