A dihydropyridine receptor alpha(1s) loop region critical for skeletal muscle contraction is intrinsically unstructured and binds to a SPRY domain of the type 1 ryanodine receptor
The II-III loop of the dihydropyridine receptor (DHPR) α1s subunit is a modulator of the ryanodine receptor (RyR1) Ca2+ release channel in vitro and is essential for skeletal muscle contraction in vivo. Despite its importance, the structure of this loop
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|Source:||The International Journal of Biochemistry and Cell Biology|
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